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FZD7 expression marks mammary tumor–initiating cells

Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. SignificanceTriple negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic options. We identify FZD7 as a key marker of tumor-initiating basal cells in the MMTV-Wnt1mouse model of TNBC and demonstrate its value as a therapeutic …

Sirt6 prevents the age-related decline of H2S through the control of one-carbon metabolism

Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. SignificanceAging is a major risk factor for multiple diseases, facing humanity with the challenge of how to prolong healthspan. Here, we explore a molecular mechanism underlying the prolongevity activity of the Sirt6 enzyme in supporting healthy aging. …

Time-of-day modulation in mosquito response persistence to carbon dioxide is controlled by Pigment-Dispersing Factor

Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. SignificanceMosquitoes use rhythmic sensory responses to find human hosts, but the role of circadian rhythms in this behavior is not well understood. Using an automated assay, we show thatAedes aegyptimosquitoes’ responses to CO2, a critical host cue, …

Spatial variation in the mutation rate within the plant shoot apical meristem

Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. SignificanceThe plant body is formed by small clusters of stem cells located at growth points, the meristems. New plant types can emerge only if mutations affect gametic and meristematic cells. Further, the shoot apical meristem consists of three cell …

Auxin transport positions stem cells in the vascular cambium during normal development and regeneration

Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. SignificancePlants are frequently subjected to injury, yet they possess remarkable ability to regenerate tissues or organs. Stem cells of vascular cambium produce xylem (wood) and phloem. When vascular cambium and the overlaying bark are removed because …

Neither inaccurate nor biased in later life: Age-related differences in the accuracy and bias of facial trustworthiness judgment

Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. SignificancePeople rely on facial appearance when deciding whether to trust others. It has been assumed that older adults make overly positive trustworthiness judgments based on facial cues, which may increase their vulnerability to fraud. However, this …

Association of Ventilatory Ratio with Acute Cor Pulmonale and Mortality in COVID-19 ARDS: A Cohort Study

Journal of Intensive Care Medicine, Volume 41, Issue 1, Page 76-85, January 2026. PurposeAn elevated ventilatory ratio (VR) and acute cor pulmonale (ACP) are associated with mortality in ARDS patients. The primary aim of this study was to assess the association between VR and ACP in patients with COVID-19-related ARDS (C-ARDS). The … Journal of Intensive Care Medicine, Volume 41, Issue 1, Page 76-85, January 2026. PurposeAn elevated ventilatory ratio (VR) and acute cor pulmonale (ACP) are associated with mortality in ARDS patients. The primary aim of this study was to assess the association between VR and ACP in patients with COVID-19-related ARDS (C-ARDS). The …

Diagnostic and Therapeutic Impact of Critical Care Echocardiography in Patients Admitted in the Intensive Care Unit for Circulatory Or Respiratory Failure Report from an Expert Center

Journal of Intensive Care Medicine, Volume 41, Issue 1, Page 48-58, January 2026. PurposeCritical Care Echocardiography (CCE) is now a major tool in assessments of ICU patients. We aimed to evaluate its clinical impact in patients admitted to the intensive care unit for acute respiratory failure (ARF) or shock.MethodsWe conducted a … Journal of Intensive Care Medicine, Volume 41, Issue 1, Page 48-58, January 2026. PurposeCritical Care Echocardiography (CCE) is now a major tool in assessments of ICU patients. We aimed to evaluate its clinical impact in patients admitted to the intensive care unit for acute respiratory failure (ARF) or shock.MethodsWe conducted a …

Early Rehabilitation for Patients with Septic Shock Associated with Mobilization During Their Intensive Care Unit Stay Without Worsening Mortality: A Multicenter, Prospective, Cohort Study

Journal of Intensive Care Medicine, Volume 41, Issue 1, Page 29-38, January 2026. Objectives:Early rehabilitation of critically ill patients has been reported to have benefits such as recovery of physical function at the time of discharge and increasing ventilator-free days, but there is also a risk of increasing the mortality rate. … Journal of Intensive Care Medicine, Volume 41, Issue 1, Page 29-38, January 2026. Objectives:Early rehabilitation of critically ill patients has been reported to have benefits such as recovery of physical function at the time of discharge and increasing ventilator-free days, but there is also a risk of increasing the mortality rate. …

Disputed Jordan codices reveal age variations under ion-beam scrutiny

Scientists have delivered the most detailed assessment yet of a set of disputed lead books known as the Jordan codices. With debate centered on whether they could date back to the early Christian period, a study led by the University of Surrey's Ion Beam Center has now shed new light on their origin.

PFAS in ski wax: Forever chemicals hit the slopes

PFAS—short for per- and polyfluoroalkyl substances—are currently the subject of numerous discussions and legislative proposals. Many of these so-called "forever chemicals" are harmful to human health and the environment. Since they can potentially remain in the environment for centuries and accumulate in humans and animals, it is important to restrict their use as much as possible. This is a challenge, as PFAS are widely used in numerous everyday objects and industrial processes.

How bacteria 'feel' surfaces: Fluorescent probe visualizes and quantifies membrane tension

In natural environments, bacteria rarely live as free-swimming cells but are attached to surfaces as biofilms in medical devices, mobile phones or human tissue. The bacterial behavior, how they attach and grow, group together or excrete compounds that glue the biofilm, is influenced by their mechanical interaction with the surface.

Researchers launch new Kansas Flood Mapping Dashboard

For Jude Kastens, who grew up on a farm in northwest Kansas, rainfall was always serious business. Although flooding wasn't as big a problem in his hometown as in central and eastern Kansas, it was "always memorable" when heavy rain caused local streams to swell from their banks into surrounding river valleys.

First complete genome of Faba Granja Asturiana legume variety released

Researchers from the Plant Genetics team of the Regional Service for Agri-Food Research and Development of the Principality of Asturias (Serida) have just published the first version of the genome of the Faba Granja Asturiana variety. This advance is key for the genetic improvement and conservation of one of Asturias' most emblematic legumes.

CT scans reveal hidden details of ancient copper smelting in early Iran

About 5,000 years ago, people living in what is now Iran began extracting copper from rock by processing ore, an activity known as smelting. This monumental shift gave them a powerful new technology and may have marked the birth of metallurgy. Soon after, people in different parts of the world were using copper and bronzes (alloys of copper and tin, or copper and arsenic) to produce decorative objects, weapons, tools, and more.