Search Medical Journals & Research Articles

Bis-pseudoindoxyls: A new class of single benzene-based fluorophores for bioimaging applications

Fluorophores are chemical compounds or molecules that absorb light energy at one wavelength and re-emit it as light at a longer, lower-energy wavelength, acting as glowing tags or markers. The absorption process is known as excitation, and the re-emission is visible as fluorescent light, which makes these molecules crucial for biological imaging, diagnostics, and tracing cellular molecules like proteins or lipids under normal or various infectious conditions.

Rocks and rolls: The computational infrastructure of earthquakes and physics of planetary science

Sometimes to truly study something up close, you have to take a step back. That's what Andrea Donnellan does. An expert in Earth sciences and seismology, she gets much of her data from a bird's-eye view, studying the planet's surface from the air and space, using the data to make discoveries and deepen understanding about earthquakes and other geological processes.

Why don't antibiotic-making bacteria self-destruct?

Early in 2025, scientists discovered a promising new antibiotic in a soil sample from a lab technician's backyard. The molecule, called lariocidin, is produced by the microbe Paenibacillus and shows broad activity against pathogenic bacteria, including several that are multi-drug-resistant. Now, the researchers report in ACS Infectious Diseases how Paenibacillus avoids harm by its own antibiotic—information that is crucial for developing lariocidin or similar compounds into new drug candidates.

Whether or not US acquires Greenland, the island will be at the center of a massive military build-up in the Arctic

Donald Trump is clearly in a hurry to dominate the political narrative in his second term of office. He began 2026 with strikes in Syria against Islamic State groups, the kidnapping of Venezuelan president Nicolás Maduro, threats to intervene in Iran and the declaration that the US would take control of Greenland—by hook or by crook.

From a new flagship space telescope to lunar exploration, global cooperation will make 2026 an exciting year for space

In 2026, astronauts will travel around the moon for the first time since the Apollo era, powerful new space telescopes will prepare to survey billions of galaxies, and multiple nations will launch missions aimed at finding habitable worlds, water on the moon and clues to how our solar system formed.

Black Ivory coffee: Elephant gut bacteria may contribute to its smooth, chocolaty flavor

Coffee beans that pass through the digestive tracts of animals get their unique flavors from the activity of gut microbes, report researchers from the Institute of Science Tokyo. The guts of Asian elephants that produce Black Ivory coffee (BIC) were rich in pectin-digesting bacteria. Heat-driven degradation of pectin during roasting makes coffee bitter. Bacterial activity that reduces the pectin content of BIC could be the source of its smoother, chocolaty, and less bitter flavor.

An innovative new tool draws on emojis to improve consumer sentiment analysis

In today's hyperconnected world, social media has become a critical channel for businesses to understand consumers. While social listening tools are widely used, they often fall short, providing only a superficial understanding of consumer sentiment. Existing methods struggle to capture the full spectrum of emotions beyond basic sentiment (positive, negative, neutral), hindering companies' ability to truly understand their customers and make informed decisions.

A new form of graphene-derived material could unlock next-generation printed electronics

Graphene has long been hailed as a "wonder material." It is incredibly strong, highly conductive and almost impossibly thin—just one atom thick. These properties make it a promising candidate for next-generation technologies such as flexible electronics, wearable devices and printed sensors. Yet despite years of research, turning graphene into practical, printable inks has remained a major challenge.

Study shows how kidnapping of athlete's father influenced society, president across continents

Sports are often viewed as an escape from the problems of the real world. But when a Colombian soccer star's father was kidnapped, the resulting media coverage helped move the story from the field of play to front-page news that united a country, cast doubt on peace negotiations and influenced how people viewed a president on multiple continents.

Rural coworking spaces thrive on community ties and mixed funding models

Coworking spaces have emerged as an alternative to traditional workplaces. Driven by the COVID-19 pandemic and the rise of remote working, these spaces are becoming increasingly common in cities, as well as in rural areas, where they hold promise for community engagement and local development, but also face challenges such as funding and long-term viability.

Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes

Nature Medicine, Published online: 14 January 2026; doi:10.1038/s41591-025-04105-8 Researchers studied the blood-based metabolome of over 23,000 people from ten ethnically diverse cohorts. They identified 235 metabolites associated with future risk of type 2 diabetes (T2D). By integrating genetic and modifiable lifestyle factors, their findings provide insights into T2D mechanisms and could improve risk prediction and inform precision prevention. Nature Medicine, Published online: 14 January 2026; doi:10.1038/s41591-025-04105-8 Researchers studied the blood-based metabolome of over 23,000 people from ten ethnically diverse cohorts. They identified 235 metabolites associated with future risk of type 2 diabetes (T2D). By integrating genetic and modifiable lifestyle factors, their findings provide insights into T2D mechanisms and could improve risk prediction and inform precision prevention.

Preempting the Trough of Disillusionment in Surgical AI

Artificial intelligence (AI) is being hailed as a panacea in clinical decision-making, operational efficiency, and quality improvement. However, its use in real-world clinical settings remains limited. Thornton et al describe implementation and deimplementation of the OR Black Box, an intraoperative data collection and analysis product (Surgical Safety Technologies, Inc), outlining several challenges in implementing and extracting value from the tool. These challenges arose from unmet expectations of functionality, its need for extensive local algorithmic training, and latency in the delivery of insights. As more AI systems are deployed, we will soon find ourselves in a “trough of disillusionment” unless important steps are taken.

Minor Papillotomy for Pancreas Divisum and Idiopathic Recurrent Pancreatitis

Given that the etiology of pancreatitis often remains idiopathic, many patients develop acute recurrent or even chronic pancreatitis that significantly affects their quality of life. A long-held belief was that the anatomical and morphological features of the pancreatic duct, particularly pancreas divisum, could play a role in the pathophysiology of recurrent pancreatitis. Pancreas divisum is a congenital condition in which the ventral and dorsal ducts fail to fuse, leading the smaller dorsal duct to provide drainage of the pancreas body and tail through the smaller duct of Santorini across the minor papilla instead of the usual drainage through the duct of Wirsung across the ampulla of Vater. The prevalence of pancreas divisum is estimated to be up to 10% in the general population and it is usually an incidental finding on radiographic imaging. Pancreas divisum is the most common congenital anomaly of the pancreatic duct and it is thought to increase the potential for duct obstruction via impaired drainage.

Completed PDUFA VII Deliverables

Since the passage of the Prescription Drug User Fee Act (PDUFA) in 1992, user fees have played an important role in expediting the drug approval process while ensuring their safety and efficacy. PDUFA must be reauthorized every five years, and in September 2022, the President signed into law the six

Guiding Principles of Good AI Practice in Drug Development

CDER and CBER have collaborated with the European Medicines Agency (EMA) to develop 10 guiding principles that industry and product developers can consider when using artificial intelligence (AI) to advance drug and biological product development. To fully realize the potential of AI while ensuring reliability of the information to ensure patient safety and regulatory excellence, it is essential to establish guiding principles that address the unique challenges and considerations of AI applications in drug development. The 10 principles are tailored to the drug development cycle and emphasize the importance of: