Circulating metabolites, genetics and lifestyle factors in relation to future risk of type 2 diabetes

Nature Medicine, Published online: 14 January 2026; doi:10.1038/s41591-025-04105-8 Researchers studied the blood-based metabolome of over 23,000 people from ten ethnically diverse cohorts. They identified 235 metabolites associated with future risk of type 2 diabetes (T2D). By integrating genetic and modifiable lifestyle factors, their findings provide insights into T2D mechanisms and could improve risk prediction and inform precision prevention. Nature Medicine, Published online: 14 January 2026; doi:10.1038/s41591-025-04105-8 Researchers studied the blood-based metabolome of over 23,000 people from ten ethnically diverse cohorts. They identified 235 metabolites associated with future risk of type 2 diabetes (T2D). By integrating genetic and modifiable lifestyle factors, their findings provide insights into T2D mechanisms and could improve risk prediction and inform precision prevention.