FZD7 expression marks mammary tumor–initiating cells

Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. SignificanceTriple negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic options. We identify FZD7 as a key marker of tumor-initiating basal cells in the MMTV-Wnt1mouse model of TNBC and demonstrate its value as a therapeutic …