Sirt6 prevents the age-related decline of H2S through the control of one-carbon metabolism

Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. SignificanceAging is a major risk factor for multiple diseases, facing humanity with the challenge of how to prolong healthspan. Here, we explore a molecular mechanism underlying the prolongevity activity of the Sirt6 enzyme in supporting healthy aging. …