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Biting the Tail of CAR-T for Relapsed Multiple Myeloma

Progress in the treatment of relapsed or refractory multiple myeloma has been rapid since the introduction of T-cell–redirecting immunotherapies. The identification of B-cell maturation antigen (BCMA) led to the approvals of three bispecific antibodies, two chimeric antigen receptor T-cell (CAR-T) therapies, and an antibody drug conjugate. Talquetamab, a bispecific antibody… Progress in the treatment of relapsed or refractory multiple myeloma has been rapid since the introduction of T-cell–redirecting immunotherapies. The identification of B-cell maturation antigen (BCMA) led to the approvals of three bispecific antibodies, two chimeric antigen receptor T-cell (CAR-T) therapies, and an antibody drug conjugate. Talquetamab, a bispecific antibody…

Gene Therapy for Nephropathic Cystinosis

Cystinosis is a prototypical lysosomal storage disease caused by recessive pathogenic variants in CTNS, which encodes cystinosin, a ubiquitous proton-driven lysosomal cystine transporter.1 Loss of cystinosin leads to intralysosomal cystine accumulation, impaired lysosomal signaling, defective autophagy, and widespread cellular dysfunction.2-4 The most severe and…

Hematopoietic Stem-Cell Gene Therapy for Cystinosis

Gene therapy for cystinosis, a lysosomal storage disease, led to decreased white-cell cystine levels and stopping or decreasing cysteamine; adverse events were mainly consistent with the myeloablative regimen and underlying disease.

Hitting the Mark — Individualizing Therapy for HER2-Positive Early-Stage Breast Cancer

Over the course of the past three decades, human epidermal growth factor receptor 2 (HER2)–targeted treatment has dramatically transformed outcomes for patients with HER2-positive breast cancer across both early- and late-stage disease. HER2 has also emerged as a clinically meaningful biomarker in several tumor types, with HER2-targeted therapies showing substantial… Over the course of the past three decades, human epidermal growth factor receptor 2 (HER2)–targeted treatment has dramatically transformed outcomes for patients with HER2-positive breast cancer across both early- and late-stage disease. HER2 has also emerged as a clinically meaningful biomarker in several tumor types, with HER2-targeted therapies showing substantial…

Phase 1 Study of Rezatapopt, a p53 Reactivator, in TP53 Y220C–Mutated Tumors

In a phase 1 study of the oral p53 reactivator rezatapopt in heavily pretreated patients with TP53 Y220C–mutated solid tumors, the most common adverse events were nausea and vomiting, and the overall response was 20%.

Effects of Radiotherapy in Normal Tissue

This review summarizes advances in radiotherapy that reduce injury to normal tissue, including improvements in the precision of imaging and delivery, and outlines strategies to prevent and manage treatment-related side effects.

Vulvar Melanoma with Vaginal Extension

A 49-year-old woman presented with a 6-month history of an itchy lump on her vulva. Examination showed a painless purple mass originating in the labia minora on the left side.

[Articles] Multiple instance learning approach for automated gallbladder cancer detection using ultrasound imaging: multi-center validation of a deep learning model with the public dataset contribution

While complex architectures like TransMIL perform well internally, GAIA-MIL offers the optimal balance of performance and generalizability for multi-center deployment. The AURORA-GB benchmark dataset is publicly released to advance research.

[Statement] CONSORT-Children and Adolescents (CONSORT-C) 2026 extension statement: enhancing the reporting and impact of paediatric randomised trials

Appropriately designed, conducted, and reported randomised controlled trials (RCTs) in children and adolescents inform treatment and health-care decisions made by young people, families, researchers, clinicians, regulators, funders, policy makers, and other interest holders. To critically evaluate, interpret, and apply trial results, readers require access to a complete and transparent report of what was planned, done, and found, taking unique considerations specific to children and adolescents into account.

[Statement] SPIRIT-Children and Adolescents (SPIRIT-C) 2026 extension statement: enhancing the reporting and usefulness of paediatric randomised trial protocols

Randomised controlled trial (RCT) protocols contain essential details needed to understand and evaluate the trial's planned aims, design, data collection methods, monitoring, data analysis, and participants' safety. However, key information is often omitted from paediatric RCT protocols, including details on dose adjustments of interventions based on age, body surface area, or weight; developmental appropriateness of trial outcome measures and processes; or strategies to minimise participants' anxiety and pain.

[Articles] Efficacy of a smartphone game to increase age and condom use at first sex among adolescents in Kenya (Tumaini): a randomised controlled trial

The results of the study provide evidence to support the potential of digital behavioural HIV prevention, serious games for sexual health, and pre-sexual risk intervention among adolescents in sub-Saharan Africa.

[Articles] The association between academic pressure and adolescent depressive symptoms and self-harm: a longitudinal, prospective study in England

Our findings support the hypothesis that academic pressure is a potential modifiable risk factor for adolescent depressive symptoms, and possibly self-harm. Interventions to reduce academic pressure could be developed and evaluated.

[Articles] Universal school-based transdiagnostic interventions to improve mental health and wellbeing among Chinese adolescents: a two-group, cluster-randomised controlled trial

The reduction in depression and anxiety symptoms 3 months after completing ten AMHSP sessions indicates a slow but meaningful benefit of the programme and supports the potential of a low-intensity, curriculum-integrated approach to promoting adolescent mental health. Delivery of the AMHSP by trained school-based mental health teachers demonstrates a scalable strategy for early mental health promotion in schools.

[Articles] Age distribution of respiratory syncytial virus disease in children younger than 5 years in low-income and middle-income countries: a systematic review and meta-analysis

Our findings reaffirm the importance of immunising the youngest infants who bear the greatest burden of severe RSV outcomes. Our estimates should allow more precise quantification of the potential impact of RSV prevention strategies across the full range of RSV disease severity in children younger than 5 years.

[Corrections] Correction to Lancet Child Adolesc Health 2026; 10: 255–64

Luo X, Zhang Q, Qu D, et al. Universal school-based transdiagnostic interventions to improve mental health and wellbeing among Chinese adolescents: a two-group, cluster-randomised controlled trial. Lancet Child Adolesc Health 2026; 10: 255–64—In figure 1 of this Article, the number of students in the control group who completed the post-intervention survey should have been 2362. This correction has been made to the online version as of March 10, 2026, and the printed version is correct.