[Correspondence] Rethinking isoflurane for paediatric ICU sedation – Authors' reply

We thank Juliane Engel and colleagues and E Alexis Bragg and colleagues for their detailed commentaries on the IsoCOMFORT trial, which emphasise the ongoing challenges related to sedation in paediatric intensive care.1 The search for the ideal sedative molecule continues, highlighting the need for rigorous and ongoing clinical research guided by robust methodologies and evidence.