[Correspondence] Rethinking isoflurane for paediatric ICU sedation

The IsoCOMFORT trial by Jordi Miatello and colleagues represents a substantial contribution to paediatric sedation research.1 The study shows non-inferiority of isoflurane to midazolam in achieving target sedation in children aged 3–17 years and is associated with reduced opioid requirements and faster wake-up times. The accompanying Comment by Maria Cristina Mondardini and Angela Amigoni rightly highlights the pragmatic value and feasibility of inhaled sedation with isoflurane in the paediatric population.