[Correspondence] From asthma theory to practice: insights from real life

We congratulate Celeste Porsbjerg and colleagues for their Series paper1 addressing a key question in asthma care: the definition of the ideal candidate for biological therapy. Porsbjerg and colleagues elegantly highlight how current definitions of remission overlook the biological mechanisms driving disease progression. Their proposed at-risk asthma framework rightly shifts attention from symptom burden to biological activity, emphasising the need for multimodal assessment to identify a crucial therapeutic window before irreversible structural remodelling occurs.