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A therapeutic peptide vaccine for fibrolamellar hepatocellular carcinoma: a phase 1 trial

Nature Medicine, Published online: 24 November 2025; doi:10.1038/s41591-025-03995-y In this phase 1 trial, treatment of patients with fibrolamellar hepatocellular carcinoma with a therapeutic peptide vaccine targeting the fusion kinase DNAJB1–PRKACA, which is the driver of the disease, together with nivolumab and ipilimumab, was safe and led to encouraging preliminary clinical responses, and translational analysis showed activation of immune responses. Nature Medicine, Published online: 24 November 2025; doi:10.1038/s41591-025-03995-y In this phase 1 trial, treatment of patients with fibrolamellar hepatocellular carcinoma with a therapeutic peptide vaccine targeting the fusion kinase DNAJB1–PRKACA, which is the driver of the disease, together with nivolumab and ipilimumab, was safe and led to encouraging preliminary clinical responses, and translational analysis showed activation of immune responses.

The paradox of climate protest

Climate activism takes many forms, but one of the most visible is so-called disruptive protests. These protests are characterized by interruptions to everyday life or specific cultural events. Examples of disruptive protests include blocking construction works, throwing paint at a painting or interrupting a sporting event. These types of actions have gotten significant media coverage in recent years.

Environment and health: A connection that remains unseen in the Climate Change Conferences

In a conversation with Luciana Julião, environment editor at The Conversation Brasil, during COP30 in Belém, Fiocruz researcher and environmental health specialist Sandra Hacon explained why the integration of climate, environment and health has guided her research for two decades. Hacon has a background in biology and ecology and is a member of the Amazon Scientific Panel (Painel Científico da Amazônia), the Climate Network of the Ministry of Science, Technology and Innovation (Rede Clima), and the National School of Public Health (ENSP).

Endings and beginnings: Atacama Cosmology Telescope releases its final data, shaping the future of cosmology

There's always a touch of melancholy when a chapter that has absorbed years of work comes to an end. In the case of the Atacama Cosmology Telescope (ACT), those years amount to nearly 20—and now the telescope has completed its mission. Yet some endings are also important beginnings, opening new paths for the entire scientific community.

New substitution method enables high-precision nuclear reaction measurements using natural copper

A joint research team has made important progress in the field of photoneutron cross section measurement. The team proposed a substitution measurement method that avoids the use of expensive and hard-to-prepare high-purity isotope targets, successfully measuring the 65Cu(γ,n)64Cu reaction cross section with high precision. This method only relies on natural copper (natCu) and previously measured copper-63 (63Cu) data, without modifying experimental facility parameters, making it simple, efficient, and low-cost.

The Man in the Moon gets a new scar

I have to confess, despite spending years gazing at the night sky, telescope at the ready, tracking planets and hunting for deep sky objects, I only actually saw the Man in the Moon about five years ago. There I was, exploring lunar maria and highland regions, and I'd somehow never noticed what humans have been seeing for millennia.

From 'mail-order brides' to 'passport bros,' the international dating industry often sells traditional gender roles

Fifteen years ago, when I started studying the international dating industry, few people took the subject seriously. The term "mail-order bride" was treated as a punch line—something outdated, associated with lonely men and poor women who migrated from Eastern Europe, Asia or other places to meet their new husbands in the United States.

[Comment] Epistemic humility for physicians and scientists

A renewed focus on epistemology—the study of how knowledge is constructed and validated—is essential for addressing the challenges of 21st-century science. Central to this is cultivating epistemic humility in the training of future scientists and physicians in order to revitalize the scientific method at a time when it is urgently needed to confront global challenges such as climate change, pandemics, and the ethical development of artificial intelligence.

Belief in divine intervention shapes consumer reactions to corporate crimes and punishments

A company dumps toxic chemicals into a river to save money. Around the same time, a major storm strikes and causes damage to that same company. Is it just a coincidence? According to new research from Andrew Gershoff, professor of marketing at Texas McCombs, the answer might depend on how strongly a consumer believes in divine intervention.

Hydrogenases spill the beans: Key catalytic moves revealed

Hydrogenases catalyze the reversible splitting and production of hydrogen gas (H2), using complex catalytic cofactors comprising Earth-abundant nickel and/or iron ions. These enzymes, especially the [NiFe]-hydrogenases (fig. 1), are remarkably efficient, making them inspiring models for clean-energy technologies. Yet despite extensive study by many groups worldwide, key steps in their catalytic cycle have remained difficult to observe.

Machine learning model sharpens snowfall forecasts for the Mountain West

The varied topography of the Western United States—a patchwork of valleys and mountains, basins and plateaus—results in minutely localized weather. Accordingly, snowfall forecasts for the mountain West often suffer from a lack of precision, with predictions provided as broad ranges of inch depths for a given day or storm cycle.

When trade routes shift, so do clouds: Researchers uncover ripple effects of new global shipping regulations

When militia attacks disrupted shipping lanes in the Red Sea, few imagined the ripple effects would reach the clouds over the South Atlantic. But for Florida State University atmospheric scientist Michael Diamond, the rerouting of cargo ships offered a rare opportunity to clarify a pressing climate question—How much do cleaner fuels change how clouds form?

Scientists track recent solar flare disruptions in Earth's ionosphere

As this month's string of powerful X-class solar flares sparked brilliant auroras that lit up skies across an unusually wide swath of the globe—from northern Europe to Florida—researchers at NJIT's Center for Solar-Terrestrial Research (CSTR) captured a less visible, but crucial, record of the storm's impact on Earth's upper atmosphere.

[Comment] Strengthening student mental health support systems in India: reflections on the Supreme Court's landmark guidelines

On July 25, 2025, the Hon'ble Supreme Court of India issued fifteen binding guidelines to prevent student suicides, in a landmark judgment delivered by Justices Vikram Nath and Sandeep Mehta in Sukdeb Saha v. State of Andhra Pradesh & Ors.1 These guidelines mark a significant step toward strengthening mental health support systems across educational institutions and coaching centres. These are broad in scope and encompass elements such as accessible mental health policies, counselling services, training of teaching and non-teaching staff, establishment of referral protocols, redressal pathways, and other protective measures.

GDUFA IV: Fiscal Years 2028 – 2032

In September 2022, the FDA User Fee Reauthorization Act of 2022 (FDAUFRA) was enacted, which included the third reauthorization of the Generic Drug User Fee Amendments (GDUFA). The current legislative authority for GDUFA III expires in September 2027. At that time, new legislation will be required for FDA to continue collecting generic drug user fees in future fiscal years to fund the process for the review of generic drug product applications. Information related to FDA’s preparation for the fourth reauthorization of GDUFA will be hosted on this page as it becomes available. GDUFA IV Reauthorization Kickoff Public Meeting - July 11, 2025