[Articles] Virological and drug-resistance outcomes for people living with HIV initiating or switching to tenofovir, lamivudine, and dolutegravir in six PEPFAR-supported countries: a prospective cohort study

High rates of viral suppression in response to tenofovir–lamivudine–dolutegravir therapy in individuals who had suppression before switching support international treatment guidelines for this population. Findings on resistance mutations and tenofovir diphosphate concentrations suggest that incomplete adherence was a key factor in the suboptimal outcomes of people with virological failure at the time of switching treatment.