The Benefits of Exercise Training in Combination With Weight Loss Therapies

The primary treatment for obesity involves calorie restriction (CR) to promote dietary weight loss achieved through interventions including behavioral modification, bariatric surgery, and antiobesity medications. In adults with obesity, CR-induced weight loss enhances physical function and improves quality of life, while also reducing the burden of various obesity-related chronic conditions, including hypertension, diabetes, obstructive sleep apnea, and atherosclerotic heart disease. However, it is also associated with a decline in lean mass and bone mineral density, which increases the risk of sarcopenia and osteoporosis. When performed alongside CR, progressive resistance training (RT) attenuates this loss of lean mass and bone mass, while the addition of aerobic training (AT) further improves cardiorespiratory fitness. The individual benefits of RT and AT are complementary, and combining both exercise training modalities during CR provides the most optimal benefits for body composition and physical function. The World Health Organization recommends that adults engage in at least 150 min of moderate-intensity or 75 min of vigorous-intensity AT weekly and participate in RT activities involving major muscle groups at least 2 days per week. While this recommendation applies to the general adult population, regular exercise training that incorporates both RT and AT is particularly crucial for adults with obesity undergoing weight loss interventions. This clinical perspective highlights the benefits of exercise training alongside current weight loss strategies, such as lifestyle changes, bariatric surgery, and pharmacotherapy, with a focus on incretin-based therapies. Article Highlights Weight loss achieved through calorie restriction causes a decline in lean mass and bone mineral density. Progressive resistance training stimulates muscle protein synthesis even during negative energy balance and is particularly crucial for mitigating the loss of lean mass associated with calorie restriction. Aerobic training further improves cardiorespiratory fitness during calorie restriction. Combining both exercise training modalities during calorie restriction provides the most optimal benefits for body composition and physical function. 10.2337/dbi25-0001Video 1. American Diabetes Association 84th Scientific Sessions: Diabetes Journal Symposium–Shifting from Quantity to Quality.d66be569-74dc-4ed8-9c83-67582847b6f7