[Personal View] Reducing the threats of rodent-borne zoonoses requires an understanding and leveraging of three key pillars: disease ecology, synanthropy, and rodentation

Rodents have co-existed with humans for centuries, and frequently exchange pathogens. Historically, rodent-driven plague outbreaks scoured the Old World, resulting in substantial human mortality. Although such pandemics have not occurred for centuries, serious threats from rodent-borne infections, such as the global emergence of mpox, still exist. Moreover, endemic and emerging rodent infections continue to cause substantial human morbidity and mortality in low-income and middle-income countries.