Peptide Electrostatic Modulation Directs Human Neural Cell Fate (Adv. Sci. 2/2026)

Human Neural Progenitor Cells Self‐assembling peptides can form dynamic scaffolds that mimic the cellular microenvironment. By tuning their electrostatic charges, these supramolecular fibers create distinct biological outcomes: negatively charged environments support neuronal commitment, while positively charged ones induce cell stress and apoptosis. This study reveals how electrostatic modulation in peptide assemblies can direct human neural cell fate, offering new strategies for regenerative medicine and biomaterial design. More details can be found in the Research Article by Aitziber L. Cortajarena, Zaida Álvarez, Ivan R. Sasselli, and co‐workers (DOI: 10.1002/advs.202507946). Human Neural Progenitor Cells Self-assembling peptides can form dynamic scaffolds that mimic the cellular microenvironment. By tuning their electrostatic charges, these supramolecular fibers create distinct biological outcomes: negatively charged environments support neuronal commitment, while positively charged ones induce cell stress and apoptosis. This study reveals how electrostatic modulation in peptide assemblies can direct human neural cell fate, offering new strategies for regenerative medicine and biomaterial design. More details can be found in the Research Article by Aitziber L. Cortajarena, Zaida Álvarez, Ivan R. Sasselli, and co-workers (DOI: 10.1002/advs.202507946 ). Advanced Science, Volume 13, Issue 2, 9 January 2026.