Search Medical Journals & Research Articles

Baker’s Cyst

A 63-year-old woman with psoriatic arthritis presented with a 9-month history of pain in the left knee. A nontender, palpable mass was present in the left popliteal fossa, which had a “speech bubble” shape on ultrasonography.

Efficacy and Safety of Obinutuzumab in Active Systemic Lupus Erythematosus

In patients with SLE without advanced lupus nephritis, obinutuzumab plus standard therapy was superior to placebo plus standard therapy in conferring and sustaining a clinically meaningful reduction in disease activity over 52 weeks.

Efgartigimod for Fetal Acetylcholine Receptor Antibody–Related Disorder

Use of off-label efgartigimod (a neonatal Fc receptor blocker) for fetal acetylcholine receptor antibody–related disorder during a pregnancy stabilized maternal antibodies and led to normal fetal development and a healthy birth.

A 12,000-Year-Old Case of NPR2-Related Acromesomelic Dysplasia

Rare disease in an adolescent who lived more than 12,000 years ago, along with her burial embrace by a first-degree relative, may reflect the importance of care for survival. Ancient DNA analysis led to a genetic diagnosis.

Majocchi’s Granuloma

A high-school wrestler presented with an itchy rash that had worsened despite topical antifungal and glucocorticoid treatment. A circular, scaly plaque with papules, nodules, and pustules was seen on his calf.

The Things We Carry

The ID, the pen, the epinephrine, the scalpel are the nonnegotiables, the necessities for any hospital shift. But they are not the only things a physician carries, and certainly not the most burdensome.

Sudden Cardiac Arrest in Athletes

Sudden cardiac arrest in athletes may be attributable to cardiac and noncardiac causes. With diagnosis and treatment, a return to play may be reasonable. Prevention, emergency planning, and shared decision making are key.

Pneumocystis jirovecii Pneumonia

A 60-year-old man with recently diagnosed HIV infection presented with a 10-day history of fever, dry cough, and shortness of breath. A CT scan of the chest showed diffuse nodules and ground-glass opacities.

LVAD

When a man ends up in the ED after having severed the driveline of his left ventricular assist device, the medical student on his team learns that sometimes a life saved is not the life the patient wants to live.

Primary Measles Infection

A previously healthy man presented with a 5-day history of fever, nausea, and vomiting and a 2-day history of an itchy rash. Examination showed an exanthem consisting of minute macules and subtly elevated papules.

Perioperative Enfortumab Vedotin and Pembrolizumab in Bladder Cancer

In cisplatin-ineligible patients with muscle-invasive bladder cancer, enfortumab vedotin–pembrolizumab plus surgery led to better event-free survival (74.7%, vs. 39.4%) and overall survival (79.7%, vs. 63.1%) than surgery alone at 2 years.

Heads or the Tail?

Survival in patients with cancer, affected by myriad factors, is notoriously difficult to predict. But while oncologists find it hard to communicate the uncertainty, patients are the ones who must live it.

Case 6-2026: A 91-Year-Old Man with Shortness of Breath, Weight Loss, and Eosinophilia

A 91-year-old man was admitted to the hospital with weight loss, dyspnea, and eosinophilia. An anteroposterior chest radiograph obtained 2 months earlier showed bibasilar patchy opacities. A diagnosis was made.

Biting the Tail of CAR-T for Relapsed Multiple Myeloma

Progress in the treatment of relapsed or refractory multiple myeloma has been rapid since the introduction of T-cell–redirecting immunotherapies. The identification of B-cell maturation antigen (BCMA) led to the approvals of three bispecific antibodies, two chimeric antigen receptor T-cell (CAR-T) therapies, and an antibody drug conjugate. Talquetamab, a bispecific antibody… Progress in the treatment of relapsed or refractory multiple myeloma has been rapid since the introduction of T-cell–redirecting immunotherapies. The identification of B-cell maturation antigen (BCMA) led to the approvals of three bispecific antibodies, two chimeric antigen receptor T-cell (CAR-T) therapies, and an antibody drug conjugate. Talquetamab, a bispecific antibody…

Gene Therapy for Nephropathic Cystinosis

Cystinosis is a prototypical lysosomal storage disease caused by recessive pathogenic variants in CTNS, which encodes cystinosin, a ubiquitous proton-driven lysosomal cystine transporter.1 Loss of cystinosin leads to intralysosomal cystine accumulation, impaired lysosomal signaling, defective autophagy, and widespread cellular dysfunction.2-4 The most severe and…