The function of Mak16 in ribosome biogenesis depends on its [4Fe-4S] cluster

Proceedings of the National Academy of Sciences, Volume 122, Issue 46, November 2025. SignificanceThis study identifies an iron–sulfur (Fe/S) cluster in the 60S ribosomal assembly factor Mak16 as essential for maintaining complex stability with its interacting partner Rpf1, which is crucial for the maturation of 25S ribosomal RNA (rRNA) …