Structure of human green cone opsin yields insights into mechanisms underlying the rapid decay of its active, signaling state

Proceedings of the National Academy of Sciences, Volume 122, Issue 49, December 2025. SignificanceOur daylight vision uses cone opsins. Unfortunately, we know less about these light-sensitive GPCRs, in part because their active state is unstable and decays within seconds (~100× faster than rhodopsin). We studied wild-type human green cone …