Structural insights into the role of eIF3 in translation mediated by the HCV IRES

Proceedings of the National Academy of Sciences, Volume 122, Issue 49, December 2025. SignificanceVarious RNA viruses utilize RNA elements called internal ribosomal entry sites (IRESs) to hijack host ribosomes. The Hepatitis C virus (HCV) IRES binds to eukaryotic initiation factor 3 (eIF3), the multisubunit complex that acts as a versatile …