Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing

Proceedings of the National Academy of Sciences, Volume 122, Issue 47, November 2025. SignificanceThe PAC1R is a potential drug target for the treatment of migraine and other central nervous system disorders yet remains underutilized as a target. PAC1R exists as multiple splice variants, including PAC1R null variant (PAC1nR) and PAC1R …