Small siphophage binding to an open state of the LptDE outer membrane lipopolysaccharide translocon

Proceedings of the National Academy of Sciences, Volume 122, Issue 48, December 2025. SignificanceThe outer membrane (OM) of Gram-negative bacteria is a protective barrier generated by lipopolysaccharide (LPS), a complex glycolipid that makes up the outer leaflet of the OM. Following its synthesis and transport from the inner membrane, LPS …