Single Cell and Spatial Transcriptomics Define a Proinflammatory and Profibrotic Niche After Kidney Injury (Adv. Sci. 2/2026)

Proinflammatory and Profibrotic Niche After Kidney Injury On this cover, layered terraces represent kidney spatial layers, with circular niches in the outer medulla where blooming water hyacinths symbolize tenascin C. These flowers attract apple snails as macrophages, depicting how niche‐specific microenvironments drive inflammation and fibrosis revealed by single‐cell and spatial transcriptomics profiling in the Research Article by Li Li, Haiyan Fu, Youhua Liu, and co‐workers (DOI: 10.1002/advs.202503691). Proinflammatory and Profibrotic Niche After Kidney Injury On this cover, layered terraces represent kidney spatial layers, with circular niches in the outer medulla where blooming water hyacinths symbolize tenascin C. These flowers attract apple snails as macrophages, depicting how niche-specific microenvironments drive inflammation and fibrosis revealed by single-cell and spatial transcriptomics profiling in the Research Article by Li Li, Haiyan Fu, Youhua Liu, and co-workers (DOI: 10.1002/advs.202503691 ). Advanced Science, Volume 13, Issue 2, 9 January 2026.