Ribonuclease RNase Z is an evolutionarily conserved deAMPylase

Proceedings of the National Academy of Sciences, Volume 122, Issue 47, November 2025. SignificanceSelenoprotein O (SelO) is a conserved AMPylase found in bacteria and humans, underscoring its fundamental role in cellular regulation. While AMPylases act as writer enzymes by attaching AMP to proteins, the identity of the corresponding eraser …