Retinal Sensitivity in Areas of Retinal Nonperfusion

The study by Hamilton-Perais and colleagues leveraged both ultra-widefield fluorescein angiography and static automated perimetric threshold to study the association of retinal sensitivity deficits with retinal capillary nonperfusion in people with diabetic retinopathy. Developing and validating end points is a priority to design clinical trials on interventions for retinal capillary nonperfusion. The strength of this study is that the retinal sensitivity deficit was elicited across a much larger area of the retina (100°) compared with previous studies that have limited these correlation studies to the fovea or macula over 1 year.