Restoring NK Cell Cytotoxicity Post‐Cryopreservation via Synthetic Cells (Adv. Sci. 42/2025)

Boosting Cryopreserved Natural Killer Cytotoxicity In their Research Article (DOI: 10.1002/advs.202505731), Bin Qu and co‐workers present a strategy to enhance the cytotoxic activity of natural killer (NK) cells using IL‐2‐presenting synthetic cells. This approach significantly boosts the tumor‐killing function of both freshly isolated and cryopreserved NK cells‐including CAR‐engineered NK cells. Notably, synthetic cells displaying IL‐15 produce similar effects. This innovative platform provides a powerful and clinically relevant method to advance off‐the‐shelf NK cell‐based immunotherapies. Boosting Cryopreserved Natural Killer Cytotoxicity In their Research Article (DOI: 10.1002/advs.202505731 ), Bin Qu and co-workers present a strategy to enhance the cytotoxic activity of natural killer (NK) cells using IL-2-presenting synthetic cells. This approach significantly boosts the tumor-killing function of both freshly isolated and cryopreserved NK cells-including CAR-engineered NK cells. Notably, synthetic cells displaying IL-15 produce similar effects. This innovative platform provides a powerful and clinically relevant method to advance off-the-shelf NK cell-based immunotherapies. Advanced Science, Volume 12, Issue 42, November 13, 2025.