Reprogramming tumor microenvironment via systemic delivery of TLR3 agonist and manganese nanoparticle

Proceedings of the National Academy of Sciences, Volume 122, Issue 45, November 2025. SignificanceDespite the promise of Toll-like receptor agonists as immune adjuvants, their antitumor efficacy has been limited in the clinic. Here, we report the development of a lipid nanoparticle system (PLCMP) designed for codelivery of a TLR3 agonist …