Recovery of infectious recombinant human norovirus using zebrafish embryos

Proceedings of the National Academy of Sciences, Volume 122, Issue 49, December 2025. SignificanceHuman norovirus (HuNoV) is a clinically important pathogen. However, progress in developing antivirals and vaccines has been hampered by the lack of a robust reverse genetics system, a technique used to engineer recombinant viruses, for HuNoV. …