Osmotically Tunable Microdroplets Enable Amplification‐Free CRISPR Detection of Gene Doping (Adv. Sci. 48/2025)

Amplification‐Free Detections This illustration connects gene doping to an innovative diagnostic solution. A microfluidic device generates osmotically tunable double emulsion droplets that serve as isolated picoliter reactors. Inside, the sample is mixed with a CRISPR‐Cas system for amplification‐free, highly sensitive detection. Enhanced signals visually confirm detection, demonstrating a simple, powerful, and rapid diagnostic platform. More details can be found in the Research Article by Changmin Sung, Chang‐Soo Lee, and co‐workers (DOI: 10.1002/advs.202515861). Amplification-Free Detections This illustration connects gene doping to an innovative diagnostic solution. A microfluidic device generates osmotically tunable double emulsion droplets that serve as isolated picoliter reactors. Inside, the sample is mixed with a CRISPR-Cas system for amplification-free, highly sensitive detection. Enhanced signals visually confirm detection, demonstrating a simple, powerful, and rapid diagnostic platform. More details can be found in the Research Article by Changmin Sung, Chang-Soo Lee, and co-workers (DOI: 10.1002/advs.202515861 ). Advanced Science, Volume 12, Issue 48, December 29, 2025.