Notable advances 2025

Nature Medicine, Published online: 12 December 2025; doi:10.1038/s41591-025-04098-4 In a year that has dealt many blows to biomedical research, many breakthroughs nevertheless continued to inspire us. From regenerative medicine to reproductive technologies and everything in between — here is our selection of critical developments that moved medicine forward in 2025. Nature Medicine, Published online: 12 December 2025; doi:10.1038/s41591-025-04098-4 In a year that has dealt many blows to biomedical research, many breakthroughs nevertheless continued to inspire us. From regenerative medicine to reproductive technologies and everything in between — here is our selection of critical developments that moved medicine forward in 2025.