Nonlifestyle Treatment of Prediabetes

This Perspectives in Clinical Diabetes article reviews the nonlifestyle treatments of prediabetes and describes the limitations of even intensive lifestyle interventions. The author was motivated to write it by the recent recommendation by The Endocrine Society to use vitamin D supplementation to reduce the development of diabetes in people with prediabetes based on eight randomized studies ( 1 ). As the author of one of the studies that showed, in contrast, a slight, nonsignificant increase in diabetes incidence in the group receiving vitamin D for 1 year, I was curious about the supporting data for the recommendation and read the eight studies. Only one showed a statistically significant decrease in diabetes incidence. A more detailed description of the updated guideline follows.