Nitric oxide promotes rapid development of motility to accelerate biofilm dispersal in Vibrio cholerae

Proceedings of the National Academy of Sciences, Volume 122, Issue 49, December 2025. SignificanceBiofilm dispersal is a critical but poorly understood step in the lifecycle of bacterial pathogens. We identify nitric oxide (NO), a host immune signal, as a rapid and specific trigger for biofilm dispersal inVibrio cholerae. Unlike …