[News] The Nobel celebrates tolerance

On Oct 6, 2025, the Nobel Prize in Physiology or Medicine was awarded to Mary Brunkow, Fred Ramsdale, and Shimon Sakaguchi for their discoveries around the mechanisms governing peripheral immune tolerance. Not only did their work uncover a fundamental facet of human health, it also solved a decades-old genetic mystery and breathed new life into a long-abandoned immunological concept. Whether these discoveries are now poised to transform treatment for patients with autoimmune rheumatic diseases remains to be seen.