Native metabolomics identifies pteridines as CutA ligands and modulators of copper binding

Proceedings of the National Academy of Sciences, Volume 122, Issue 48, December 2025. SignificanceWe identified the molecular class of pteridines as natural ligands of the cryptic CutA protein, including a so far unknown 2’-deoxyxanthopterin B2. Our data showed increased copper binding to CutA in the presence of pteridines. Together, these …