Multiple weak brakes act in concert to control STIM1 and store-operated calcium entry

Proceedings of the National Academy of Sciences, Volume 122, Issue 50, December 2025. SignificanceStore-operated calcium entry (SOCE) is essential for many physiological processes, and inadequate regulation of this pathway leads to a variety of human diseases. The ER calcium-sensing protein STIM1 is known to control SOCE, but a structural …