MicroRNA‐Enriched Plant‐Derived Exosomes Alleviate Colitis by Modulating Systemic Immunity, Metabolic Homeostasis, and Gut Microbiota (Adv. Sci. 42/2025)

Plant‐Derived Exosomes Rooted in millennia‐old herbal wisdom, plant‐derived exosomes emerge as potent regulators of uncontrolled inflammatory cascades in colitis. Like turbulent crimson waters surging from the upstream Yarlung Tsangpo Dam, inflammation disrupts mucosal equilibrium. Yet, Nezha, depicted on lotus leaves, releases plant‐derived exosomes enriched with miRNAs through a metaphorical conduit. This natural cross‐kingdom dialogue transforms pathological chaos into physiological harmony, restoring immune balance, metabolic balance, and gut microbial symbiosis. More details can be found in the Research Article by Dong‐Hua Yang, Zhangfeng Zhong, and co‐workers (DOI: 10.1002/advs.202505921). Plant-Derived Exosomes Rooted in millennia-old herbal wisdom, plant-derived exosomes emerge as potent regulators of uncontrolled inflammatory cascades in colitis. Like turbulent crimson waters surging from the upstream Yarlung Tsangpo Dam, inflammation disrupts mucosal equilibrium. Yet, Nezha, depicted on lotus leaves, releases plant-derived exosomes enriched with miRNAs through a metaphorical conduit. This natural cross-kingdom dialogue transforms pathological chaos into physiological harmony, restoring immune balance, metabolic balance, and gut microbial symbiosis. More details can be found in the Research Article by Dong-Hua Yang, Zhangfeng Zhong, and co-workers (DOI: 10.1002/advs.202505921 ). Advanced Science, Volume 12, Issue 42, November 13, 2025.