Mechanisms of transport and analgesic compounds recognition by glycine transporter 2

Proceedings of the National Academy of Sciences, Volume 122, Issue 48, December 2025. SignificanceChronic pain is a significant health challenge due to the limited efficacy and severe side effects of current treatments. Glycine transporter 2 (GlyT2) is a key regulator of inhibitory neurotransmission in the spinal cord and brainstem, …