Mechanically Active Hydrogel for Healing Intestinal Fistulas through the YAP‐Mediated Mechanosensitization of Intestinal Epithelial Cells (Adv. Sci. 43/2025)

Mechanically Active Hydrogel for Healing Intestinal Fistulas Effective sealing treatment of intestinal fistula avoids secondary surgery, but many challenges remain in sealing treatment. In their Research Article (DOI: 10.1002/advs.202510717), Ze Li, Jinjian Huang, Peige Wang, Jianan Ren, Xiuwen Wu, and co‐workers report a mechanically active hydrogel sealant. It sealed intestinal fistula in situ, constricted the fistula, and promoted the healing of intestinal fistula by modulating the mechanosensitivity of intestinal epithelial cells. This provides a promising strategy for sealing intestinal fistula. Mechanically Active Hydrogel for Healing Intestinal Fistulas Effective sealing treatment of intestinal fistula avoids secondary surgery, but many challenges remain in sealing treatment. In their Research Article (DOI: 10.1002/advs.202510717 ), Ze Li, Jinjian Huang, Peige Wang, Jianan Ren, Xiuwen Wu, and co-workers report a mechanically active hydrogel sealant. It sealed intestinal fistula in situ, constricted the fistula, and promoted the healing of intestinal fistula by modulating the mechanosensitivity of intestinal epithelial cells. This provides a promising strategy for sealing intestinal fistula. Advanced Science, Volume 12, Issue 43, November 20, 2025.