Machine learning enables de novo multiepitope design of Plasmodium falciparum circumsporozoite protein to target trimeric L9 antibody

Proceedings of the National Academy of Sciences, Volume 122, Issue 49, December 2025. SignificanceIn this study, we present a machine learning–driven, structure-guided protein design pipeline built specifically for the design of multiepitope vaccine antigens. We employ the pipeline here to design and solve the cryo-EM structure of a de …