LHPP expression in triple-negative breast cancer promotes tumor growth and metastasis by modulating the tumor microenvironment

Proceedings of the National Academy of Sciences, Volume 122, Issue 49, December 2025. SignificanceTriple-negative breast cancer (TNBC) is an aggressive subtype with limited treatment options. This study identifies a distinct role for the phosphohistidine phosphatase LHPP, known as a tumor suppressor in other cancers, as a promoter of TNBC …