Isoform-specific regulation of PKM by acetylation

Proceedings of the National Academy of Sciences, Volume 122, Issue 48, December 2025. SignificancePyruvate kinase (PK) catalyzes the last step in glycolysis, the pathway by which glucose is metabolized. In humans, the M1 isoform of PK (PKM1) is constitutively active, but the activity of the highly homologous PKM2 isoform is regulated by, …