Intercellular diffusion of cyclic nucleotides followed by gap junction closure restarts meiosis in mouse preovulatory follicles

Proceedings of the National Academy of Sciences, Volume 122, Issue 49, December 2025. SignificanceContinuous time-lapse imaging of cyclic AMP and cyclic GMP in mouse ovarian follicles elucidates how luteinizing hormone (LH) regulation of cyclic GMP and gap junctions in the somatic cells surrounding the oocyte transmits a signal that lowers …