IL-27 promotes Treg cell expression of CD122 and fitness at homeostasis

Proceedings of the National Academy of Sciences, Volume 122, Issue 50, December 2025. SignificanceTreg cells are a specialized population of T cells that dampen inflammation and maintain tolerance. Numerous studies highlight the ability of the cytokine IL-27 to promote Treg cell responses during inflammation, but the impact of IL-27 on …