High-resolution GlyT2 structures point to non-opioid analgesic options

Glycine is a major inhibitory neurotransmitter that reduces nerve activity, helping to regulate pain signals, motor control and sensory processing. Glycine transporter 2 (GlyT2) is a key regulator of glycinergic neurotransmission because it removes glycine from the synaptic clefts. When GlyT2 is inhibited, glycine reuptake is reduced, allowing synaptic glycine levels to rise and enhancing inhibitory signaling.