Elucidating cooperative genetic events in DCIS progression in mutant p53–driven breast cancer

Proceedings of the National Academy of Sciences, Volume 123, Issue 2, January 2026. SignificanceDuctal carcinoma in situ (DCIS) is a mammary precursor lesion with no clinical strategy to stratify indolent lesions from those that will become invasive, and the natural history of DCIS progression is unknown. The standard of care includes …