Dynamics and variegation in the Treg response to Interleukin-2

Proceedings of the National Academy of Sciences, Volume 122, Issue 47, November 2025. SignificanceInterleukin-2 (IL2) is essential for Treg cell maintenance, but how its effects on Treg cells unfold, and whether Treg cells are heterogenous in their responses to IL2, are poorly understood. By analyzing mRNA and chromatin responses to IL2 in …