Dual-targeted ping-pong CAR T cells: Leveraging peripheral expansion to improve solid tumor immunotherapy

Proceedings of the National Academy of Sciences, Volume 122, Issue 51, December 2025. SignificanceChimeric antigen receptor (CAR) T cell therapies have revolutionized treatment for B cell malignancies, where robust expansion of CAR T cells in the blood correlates with clinical success. However, in solid tumors, CAR T cells fail to expand …