Divergent GFR Estimates and Clinical Implications

Chronic kidney disease (CKD) affects more than 800 million people worldwide, significantly increasing the risk for kidney failure, cardiovascular disease, and all-cause mortality. Accurate assessment of glomerular filtration rate (GFR) is essential for identifying and managing CKD. Although GFR is most accurately measured by analyzing the rate of kidney excretion of infused exogenous substances, such as inulin or iohexol, this is not practical in most cases. Therefore, estimated glomerular filtration rates (eGFRs) have become important for CKD diagnosis and management.