Creatine kinase imaging (CKI) for in vivo whole-brain mapping of creatine kinase reaction kinetics

Proceedings of the National Academy of Sciences, Volume 122, Issue 47, November 2025. SignificanceCreatine kinase (CK) is a key enzyme in brain bioenergetics, with its activity altered in various neurological disorders. This study introduces a CK Imaging (CKI) method to map CK forward rate constants across the entire brain in vivo. …