[Correspondence] The importance of patient selection in stroke monitoring research

As the number of patients with acute ischaemic stroke receiving thrombolysis increases, identifying monitoring protocols that optimise resource use and improve patient outcomes is crucial. The OPTIMISTmain trial1 provides valuable data on the safety and efficacy of low-intensity monitoring after thrombolysis, concluding non-inferiority in safety compared with standard protocols. However, we propose that a potential source of eligibility bias linked to patient recruitment merits closer examination.