[Correspondence] Integrating metagenomic sequencing into diagnostic pathways for tuberculous meningitis – Authors' reply

Shang-Yi Lin and colleagues highlight the emerging role of metagenomic next-generation sequencing (mNGS) as a diagnostic adjunct for tuberculous meningitis. The diagnosis of tuberculous meningitis is notoriously challenging and new diagnostic approaches, such as mNGS, are much needed.1 However, the use and integration of mNGS into routine diagnostic practice must overcome the considerable challenges of cost and global availability.2 When we developed the scope of our practice guideline in 2021, these challenges had not been met; mNGS was therefore not included.