[Correspondence] Integrating metagenomic sequencing into diagnostic pathways for tuberculous meningitis

We read with interest the Review in The Lancet Infectious Diseases by Joseph Donovan and colleagues on the management of tuberculous meningitis, which emphasised the use of Xpert Ultra alongside mycobacterial culture and appropriately highlighted the limitations of current diagnostics in the context of low bacillary load.1 However, the Review does not address the potential role of metagenomic next-generation sequencing (mNGS), including nanopore-based approaches, which are increasingly applied in real-world CNS diagnostics.